In February 5, 2020, Equinox Sciences, LLC, a subsidiary of Betta Pharmaceuticals Co., Ltd., has entered into an exclusive license agreement with EyePoint Pharmaceuticals, Inc. to license out the exclusive rights for EyePoint to develop intravitreal drug delivery system for vorolanib (CM082), a tyrosine kinase inhibitor, to treat wet age-related macular degeneration and other ophthalmology diseases.
About EyePoint
EyePoint Pharmaceuticals, Inc. (www.eyepointpharma.com) is a biopharmaceutical company committed to developing and commercializing innovative ophthalmic products in indications with high unmet medical need to help improve the lives of patients with serious eye disorders. The Company currently has two commercial products: DEXYCU®, the first approved intraocular product for the treatment of postoperative inflammation, and YUTIQ®, a three-year treatment of chronic non-infectious uveitis affecting the posterior segment of the eye. The Company's pipeline leverages its proprietary bioerodible Durasert™ technology for extended intravitreal drug delivery including EYP-1901 targeting wet age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. EyePoint Pharmaceuticals is headquartered in Watertown, Massachusetts with offices in Basking Ridge, New Jersey.

Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies, and proprietary cancer vaccine platforms. Agenus has more than 26 years of experience in the development of immuno-oncology therapies and has entered into equity investments agreements as well as licensing agreements with several multinational pharmaceutical companies. The U.S. biopharmaceutical companies Incyte Corporation (NASDAQ: INCY) and Gilead Sciences, Inc. (NASDAQ: GILD) are both stockholders of Agenus and are also key collaborators of Agenus.

On June 22, 2020, Betta Pharmaceuticals Co., Ltd. announced that it has entered into an agreement with Agenus Inc. that Betta has obtained an exclusive right to develop and commercialize Balstilimab (a PD-1 mAb) and Zalifrelimab (a CTLA-4 mAb) in all uses (excluding intravesical delivery), as a monotherapy or combination therapy with other components in Greater China (including Hong Kong, Macao and Taiwan). In the meantime, Betta shall purchase Agenus’ newly-issued shares, to strength the collaboration of both parties.

Merus focuses on the clinical development of tumor immunotherapeutics, and has established the Biclonics^® platform to develop innovative human bispecific antibodies. Based on the immunoglobulin IgG, the Biclonics^® platform produces bispecific antibodies that have met industry standards. Through pre-clinical and clinical studies, the antibodies produced by this platform were found to share similar characteristics with conventional monoclonal antibodies, such as long half-life and low immunogenicity.

On December 11^th, 2018, Betta Pharma reached a strategic collaboration agreement with Merus and obtained the exclusive right to develop and commercialize MCLA-129 in China.

The mission of Repugene is to integrate precision medicine into public healthcare, developing gene sequencing technology and products. The services provided by Repugene include regular health checkup, oncogene screening and detection, research collaboration, data processing and cloud computing, artificial intelligence, immunotherapy, companion diagnostics for pharmaceutical research and development, bioinformatics analysis and etc.. Driven by its scientific collaboration, technology innovation and product development, Repugene strives for providing better clinical solutions to patients and healthcare institutes, promoting the development of the precision medicine industry..

On February 26^th, Betta Pharma signed a strategic collaboration agreement with Repugene, strengthening their collaboration on precision medicine.

Shanghai Junshi Biosciences Co., Ltd. (NEEQ: 833330, HKEX: 01877) was founded in December 2012 by a team of scientists from well-known universities in China and the U.S. with rich experience in translational medicine, technology transfer and commercialization. Junshi focuses mainly on the R&D and commercialization of innovative monoclonal antibodies and other therapeutic biologics. It has an expansive pipeline including 12 innovative drugs and one biosimilar program, is the first Chinese company whose PD-1 mAb product was approved by the NMPA, and the first Chinese company whose INDs of anti-PCSK9 and anti-BLvS mAbs were approved by the NMPA.

On July 19^th, 2018, the investigational new drug (IND) application of the combination of vorolanib (CM082) and toripalimab (brand name: Tuoyi) from Junshi was accepted by the NMPA for untreated locally advanced or metastatic melanoma.

On January 16^th, 2019, the IND was approved by the NMPA.

InventisBio, founded by U.S. returned Ph.D.s at Shanghai Zhangjiang HiTech Park in 2013, is a rapidly growing biotech company focusing on the development of innovative medicines targeting on tumor and metabolic diseases. The company currently has 4 candidate drugs targeting tumor and gout. Except for D-0316, there are 2 other candidates under phase I clinical trials in China and the U.S.. Furthermore, InventisBio also focuses on the drug development to combine with other immunotherapies.

On December 28^th, 2018, Betta Pharma reached a strategic collaboration agreement with InventsBio Inc. on the development and commercialization of D-0316 in China (including mainland, Hongkong and Taiwan).

Based in Binjiang, Hangzhou, HanX Biopharmaceuticals is an innovative biopharmaceutical company with a senior executive team comprised of overseas returnees and industry veterans, focusing on the research and development of innovative antibody therapeutics. As of now, HanX has set up the development and commercialization platforms adhering to global standards, and developed a pipeline targeting tumor, autoimmune disease, inflammation and cardiovascular disease.

In January, 2017, Betta Pharma invested in HanX Biopharmaceuticals.

Beijing Biostar Biotechnologies, Ltd. was established in Haidian Park, Zhongguancun Science and Technology Zone, Beijing in July 2002. It is a national high-tech enterprise led by a team of U.S. returnees, focusing on the discovery, technology transfer and consultation of anticancer small molecule drugs. Its leading product UTD1 is a national first-class oncology innovative drug, and it is also the first new epothilone-based anticancer drug approved for clinical trials in China, indicating Biostar’s advanced R&D capabilities.

In May, 2017, Betta Pharma invested in Beijing Biostar Technologies, Ltd.

Mabworks is a national high-tech enterprise founded by a team of overseas returnees focusing on the antibody design and research, clinical development and commercialization. Mabworks has a leading antibody discovery and development platform. Its MIL60 program, currently in the stage of clinical study, is targeting vascular endothelial growth factor (VEGF), and is being developed for 7 solid tumor indications including non-small cell lung cancer, colorectal cancer and breast cancer.

On February 28^th, 2017, Betta Pharma reached an agreement with Beijing Mabworks to collaborate on the MIL60 program, expanding Betta Pharma’s biologics pipeline.

Located in Shanghai, Anew Pharma is an innovative pharmaceutical company founded by overseas returnees, focusing on the development of the targeted therapy CM082. With the innovative business model and booming CRO clusters in China, Anew Pharma integrates various sources and applying them on innovative drug development.

On February 26^th, 2017, Betta Pharma invested 370 million RMB to acquire 77.4% of Anew Pharmaecuticals Co., Ltd., and took over the development of vorolanib (CM082).

On June 16^th, 2017, Betta Pharma acquired Anew Pharma, and owned the China right of vorolanib.

         Meryx focuses on the discovery and development of small molecule immuno-oncology therapeutics, dedicating its R&D efforts to the development of kinase inhibitors targeting Mer, to treat hematologic and solid tumor indications.

On Juy 17^th, 2017, Betta Pharma reached a strategic collaboration agreement with Meryx and obtained the exclusive right to develop and commercialize MRX-2843 in China (including mainland China, Hong Kong, Taiwan and Macau).

Hangzhou DAC Biotech is a Chinese biotech company jointly founded by U.S. returnees-comprised entrepreneurs’ team, Zhejiang pharmaceutical enterprises and venture capital firms in Yuhang, Hangzhou, 2012. The core team is built up with 5 Ph.D. returnees and 36 Ph.D. and M.A. recruited in China. Hangzhou DAC Biotech focuses on developing and commercializing antibody-conjugated drugs for targeted cancer treatments.

In December, 2015, Betta Pharma invested in Hangzhou DAC Biotech.

Equinox Science LLC is a joint venture founded by Betta Pharma and Tyrogenex in Newcastle, DE, U.S. in 2017, focusing on the co-development of vorolanib (X-82) for cancer treatments. As of now, Equinox Sciences owns the global rights of vorolanib (X-82) in oncology and ophthalmology indications except for China, and the business scope includes the development, manufacturing, commercialization and marketing of vorolanib.

In January, 2017, Betta Pharma established Equinox Sciences LLC in joint venture with Tyrogenex.

Located in Florida, U.S., Xcovery is a biopharmaceutical company focusing on the discovery and development of innovative medicines for advanced tumor treatment and improvement of cancer patient care. Xcovery has built up an oncology pipeline that targets multiple malignant diseases. The leading product, ensartinib hydrochloride (X-396), is a small molecule ALK inhibitor to treat ALK+ NSCLC patients.

On October 25^th, 2014, Betta Pharma invested 20 million US dollars in Xcovery to jointly develop a next-generation ALK inhibitor X-396 (ensartinib hydrochloride).

On July 26^th, 2017, Betta Pharma increased the holdings of Xcovery and became its controlling shareholder. Betta Pharma and Xcovery are jointly advancing the global clinical development of X-396 (ensartinib hydrochloride).

Amgen is focusing on the discovery, development, manufacturing and sales of innovative drugs, and it is devoted to benefit patients with unmet medical needs. Since its establishment in 1980, Amgen has become one of the global leading biotech companies providing innovative drugs for millions of patients in more than 100 countries and regions. The strong pipeline and the global-leading production level of Amgen ensure its quality supply as well as its leadership in biologics production. Through its scientists’ research on key disease metabolisms, Amgen develops multiple leading innovative biotherapeutics and establishes itself as a leader in the global biotechnology field.

On May 10^th, 2013, Betta Pharma signed a collaboration contract with Amgen to promote the Vectibix in China.